In June 1841 Parkes sailed for China to take up his residence at the house of his cousin, Mary Wanstall Gützlaff (née Newell), who was the wife of the missionary and explorer Karl Friedrich Gützlaff.
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The second daughter of Sir Harry, Mabel Desborough Parkes, was married to Flag Lieutenant (Royal Navy) Egerton Bagot Byrd Levett-Scrivener of Sibton Abbey, Yoxford, Suffolk.
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On September 29, two envoys, Henry Loch and Harry Parkes went ahead of the main force under a flag of truce to negotiate with the Prince I at Tungchow.
Following the election and an increased majority for Palmerston, the voices within the Whig faction who were in support of China were hushed, and the new parliament decided to seek redress from China based on the report about the Arrow Incident submitted by Harry Parkes, British Consul to Guangzhou.