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Charles was the chief physician of three French kings, Henri IV, Louis XIII and Louis XIV.
At the time of the Wars of Religion between Catholics and Protestants, it was the site of the signature of the Treaty of Nemours in 1585 between Catherine de' Medici and the Duke of Guise, which ratified the progress of the Catholic League and urged Protestants to leave the kingdom, before “good” King Henri IV finally put an end to the quarrels nearly a century later with the Edict of Nantes.
His first cousin was Nicolas-Alexandre, marquis de Ségur and other relatives include Henri IV, vicomte de Ségur, leader and nobleman, becoming Duke in France and England, and Marguerite de Ségur, HRH Albert, Prince Consort's great-grandmother, also Queen Victoria's great-grandmother making Prince Albert and Queen Victoria second if not first cousins, part of Marquessate.
Laure (1636–1657), the eldest, who married Louis de Bourbon, Duke of Vendôme, grandson of King Henri IV and his mistress, Gabrielle d'Estrées, and became the mother of the famous French general Louis Joseph, Duke of Vendôme,
In the opening scene of Act II, for example, Justice tells Love that Heroical Virtue "is gone to the Antipodes, unto Japonia" that is, Japan and that "I have not heard of him since the time of Judas Maccabeus...." The drama also displays many references to then-recent historical events, including the Gunpowder Plot and François Ravaillac's assassination of Henri IV among others.
In the early seventeenth century, Father Jean-Baptiste de Mornat, priest of Venetian origin arrived in France in the suite of Marie de' Medici, chaplain and counselor of Kings Henri IV and Louis XIII, restores the abbey.
Francesco's heir, his brother Ferdinando, was persuaded to part with them in 1597 by his niece Maria, married to Henri IV.