It is an Hfq-dependent RNA which downregulates AfaD-VIII invasin translation by binding to and initiating cleavage of its mRNA.
From this set of candidate genes, microarray analysis and northern blotting confirmed the existence of 17 previously undescribed sRNAs, many of which bind to the chaperone protein Hfq and regulate the translation of RpoS (Sigma 38).
This binding is dependent on binding to a protein called Hfq protein.
Listeria Hfq binding LhrA is a ncRNA that was identified by screening for RNA molecules which co-immunoprecipitated with the RNA chaperone Hfq.
Listeria Hfq binding LhrC this ncRNA was identified by screening for RNA molecules which co-immunoprecipitated with the RNA chaperone Hfq.
It is believed that these RNAs, guided by a protein, Hfq, can mediate the destabilisation of the quorum-sensing master regulators LuxR/HapR/VanT mRNAs.