The College was then affiliated to the University of Indore, which was established in 1964 by an act of legislative assembly of newly form Madhya Pradesh state of Independent India.
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It is situated in an area between known as Bhanwar Kua which has a high concentration of cultural and academic institutions, including the Indore University, Indian Institute of Technology Indore, Central Museum, Institute of Management Studies, Cystal IT Park and the Kamla Nehru Zoological Park.
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Holkar Science College is a prominent educational institute in Indore, Madhya Pradesh.
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