In 1910, Ricketts became interested in a strain of typhus known as tabardillo, due to a major outbreak in Mexico City, and the apparent similarity of the disease to spotted fever.
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Fenger's lectures were very popular, and over the years, he trained several prominent physicians, including William James Mayo, Charles Horace Mayo, Nicholas Senn, James B. Herrick, Ludvig Hektoen, and Howard Taylor Ricketts.