Hox gene |
The cell memory of a given positional value depends on two inputs, the first being the ability of many Hox proteins to autoactivate their own transcription, and the second derived from two large groups of transcriptional regulators: The Polycomb group and the Trithorax group.
#Knocking out Tbx4 or Tbx5 knockout prevents FGF10 expression in the lateral plate mesoderm in mice.The Hox pathway may affect Tbx expression, which in turn affects FGF10 expression.
miR-615 has been found to reside within Hox gene clusters, alongside Hox genes other miRNAs.
The Parahoxozoa are a proposed grouping of animals based on presence of at least a single Hox/ParaHox gene, uniting Placozoa, Cnidaria (jellyfish) and Bilateria.
He also studies how Hox transcription functions control morphogenesis, and how changes in the Hox proteins, cofactors, and DNA targets affect morphology.