After the death of his uncle, Antonio Cárdenas Guillén (a.k.a. Tony Tormenta) in 5 November 2010, infightings within the Gulf Cartel triggered, and Cárdenas Vela faced problems with Jorge Eduardo Costilla Sánchez (a.k.a. El Coss) and other Gulf cartel members, who at one time worked along his uncle Osiel Cárdenas Guillén.
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The death of his uncle Antonio on November 2010 created an internal division in the Gulf Cartel, but Cárdenas Vela managed to become the regional boss of the cartel in Matamoros on March 2011.
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