While possessing the Infinity Gem of Power, the Champion unconsciously used it to further increase his power with his rage, so that during his fight with Thanos his strength increased to the point where he destroyed the planet on which they were fighting.
The five Elders that were previously consumed by Galactus (Champion, Collector, Gardener, Grandmaster and Runner) are targeted by the Titan Thanos because they possess the Infinity Gems.
Inadvertently, Hardcase discovered the Time Gem, one of the Infinity Gems, and using it tried to prevent the Squad’s death.
He is later freed by Thanos, who secretly desires the Soul Gem the In-Betweener wears, as it is one of the six Infinity Gems.
Warlock expunged the good and evil portions of his personality while holding the gauntlet which limited his ability to exploit aspects of the Soul Gem.
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When Adam Warlock obtains possession of the all-powerful Infinity Gauntlet (that contained the six Infinity Gems) from Thanos, he is ordered by the Living Tribunal to separate the Gems so that they might never be used in conjunction again.
During the Heroic Age storyline, Hood escapes from prison and makes a play to assemble the Infinity Gauntlet and meets up with Madame Masque.
In the game's plot, Adam Warlock calls upon Earth's greatest super heroes to seek out the Infinity Gems before they fall into the wrong hands.
Battered and inadvertently humiliated by her, Titania was offered the chance at revenge after obtaining the Power Gem, one of the legendary Infinity Gems, from its former owner, the former Champion of the Universe, now known as the Fallen One because of his own defeat at the She-Hulk's hands.
Master Order and Lord Chaos participated in the congress of metaphysical and abstract beings to determine Thanos's fitness to wield the Infinity Gauntlet.
When Adam Warlock sought people to help him safeguard the Infinity Gems, he chose Moondragon to keep the Mind Gem—but only after erecting safeguards so Moondragon could not exploit the gem's full power.
Afterwards, Pip was given the Space Gem by Warlock, keeping it between his toes for safekeeping.
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When Warlock had control of the Infinity Gauntlet, he had forced out the good and evil sides of himself.
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Thanos destroyed Pip's mind, but Adam was able to absorb Pip's soul into the Soul Gem (killing his mindless body, but restoring full mental function to his soul), reuniting him with the spirits of Gamora and eventually Adam Warlock in Soulworld within the Soul Gem.
Recently resurrected by Death in order to wipe out half of the population of the universe, The Titan Thanos discovers the true nature of the six Infinity Gems after gazing into Death's Infinity Well.
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