Mikhail Boyarsky played the role of Inspector Lestrade in the Russian TV adaptation, Sherlock Holmes.
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Notably, Dennis Hoey played Lestrade in most of the Sherlock Holmes films from Universal Pictures starring Basil Rathbone as Holmes.
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Early on in their acquaintance, Inspector Lestrade of Scotland Yard arrives at their lodgings in Baker Street with a matter of extreme and delicate urgency regarding a brutal murder in a Whitechapel slum, and the detective is to be hired to solve the case.
He played "with chilling authority" in the words of writer David Stuart Davies, Professor Moriarty in The Baker Street Boys (1982), and "with great panache" Inspector Lestrade in the Granada Television series The Adventures of Sherlock Holmes (featuring Jeremy Brett as Holmes).
Macnaghten appears as a character in The Adventures of Inspector Lestrade (1985), ISBN 0-333-38447-4, the first of the Inspector Lestrade novels by M. J. Trow.
Inspector Lestrade of Scotland Yard brings Holmes a seemingly trivial problem about a man who shatters plaster busts of Napoleon.