Macnaghten appears as a character in The Adventures of Inspector Lestrade (1985), ISBN 0-333-38447-4, the first of the Inspector Lestrade novels by M. J. Trow.
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When Henry was appointed Commissioner in 1903, succeeding Sir Edward Bradford, Macnaghten was appointed Assistant Commissioner (Crime) and became involved in many of the most famous cases in the history of the Metropolitan Police, including the Hawley Harvey Crippen case and the Farrow double murder case, which resulted in the conviction and hanging of the Albert and Alfred Stratton largely on the basis on fingerprint evidence.
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Macnaghten also features prominently in the later chapters of Alan Moore's seminal graphic novel From Hell.
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