In anticipation of mass evacuations of the Washington Area, the Dwight D. Eisenhower National System of Interstate and Defense Highways funded the I-95 highway project.
Once in office, Eisenhower governed as a moderate progressive, approving infrastructure spending projects like the Interstate Highway System and supporting high tax rates on the rich, as well as taking a progressive stand on Civil Rights issues.
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With very rare exceptions (such as County Route 537), the 500 series follows the rule of cardinal direction used for Interstate Highways and U.S. Routes: even-numbered roads run east and west, while odd-numbered roads run north and south.
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East–west routes tend to be numbered with the lowest numbers in the northern part of the state and the highest numbers in the southern part of the state, also like the Interstate Highways and U.S. Routes.
The largest bridge to Indiana south of Lawrenceville, and the only Interstate link between Illinois and Indiana south of Terre Haute, the I-64 river crossing runs parallel to the collapsed rail bridge, about 1000 feet upstream.
Interstate 78 (I-78) is a part of the Interstate Highway System that runs from Union Township, Lebanon County, Pennsylvania, to New York City.
Interstate 95 (I-95) is a part of the Interstate Highway System that runs from Miami, Florida, to the Canada–United States border near Houlton, Maine.
The entire route of US 13 in Maryland is part of the Ocean Highway, an Atlantic coastal highway stretching from Jacksonville, Florida to New Brunswick, New Jersey that served as the quickest route between the New York City area and Florida before the introduction of the Interstate Highway System.