Irritants are typically thought of as chemical agents (for example phenol and capsaicin) but mechanical, thermal (heat), and radiative stimuli (for example ultraviolet light or ionising radiations) can also be irritants.
The EPA has described the following long-term effects when exposed to levels above the MCL in drinking water exposed to runoff from herbicide used on row crops: slight skin and eye irritation; at lifetime exposure to levels above the MCL: potential damage to liver, kidney, spleen; lining of nose and eyelids; cancer.
The hairs of the caterpillars can cause skin irritation (Urticaria).
According to former Neighbours co-star Matthew Werkmeister (Zeke), some of Stingray's more individual expressions such as "hufter" and "Belgium" (as an expression of dismay or irritation) were coined by Ben himself (although the use of 'Belgium' as a curse word was pioneered by Douglas Adams in The Hitch Hikers Guide to the Galaxy).
Another reason for the irritation was that most of FACA consisted of soldiers from Kolingba’s ethnic group, the Yakoma.
The Stem bark, root bark, twigs, stalks and seeds of the plant are used as hypotensive, non-cholinergic, relaxant smooth musculature, vasopressive, sympathicomimetic for inflammation and irritation of the upper respiratory system and the gastrointestinal tract.
Combined efforts by a team of detectives and the Dutch federal police eventually found Poetin on August 25, 2005, at an equine clinic in Kerken, Germany, where she was being officially treated for 'irritation of the right front tendon sheath.
Capsaicin (derived from Cayenne, Capsicum minimum) "incites irritation without rubefaction"
King Herod (Stratford Johns) begs his young stepdaughter Salome (Imogen Millais-Scott) to dance for him, promising to give her anything she desires, much to the irritation of her mother, Herodias (Glenda Jackson).
When his request was flatly refused, Malisoff complained with considerable irritation "that the materials handed over by him on one question alone—oil, by his estimate had yielded the Soviet Union millions during past years and the aid requested by him was trifling." Malisoff was an extremely active and important agent; his Case Officer, Leonid Kvasnikov, who specialized in scientific-technical espionage, had met with Malisoff twenty times in 1943 alone.