Constance of York (c.1374 – 28 November 1416), who married Thomas le Despenser, 1st Earl of Gloucester (22 September 1373 – 16 January 1400), third but first surviving son of Edward le Despenser and Elizabeth Burghersh, by whom she had a son, Richard, and two daughters, Elizabeth and Isabel.
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After Isabella's death, Edmund of Langley married Joan Holland, sister and co-heir of Edmund Holland, 4th Earl of Kent (9 January 1382 – 15 September 1408), with whom his daughter, Constance, had lived as his mistress (see above).
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As a result of her indiscretions, including an affair with King Richard II's stepbrother, John Holland, 1st Duke of Exeter (d.1400), whom Pugh terms 'violent and lawless', Isabella left behind a tarnished reputation, her loose morals being noted by the chronicler Thomas Walsingham.
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After the death of her husband she was either betrothed to or lived as the mistress of Edmund Holland, 4th Earl of Kent (9 January 1382 – 15 September 1408), and had a daughter by him, Eleanor Holland (died c. 1459), who married James Tuchet, 5th Baron Audley.
Castile | Alfonso X of Castile | Kingdom of Castile | Crown of Castile | Isabella I of Castile | Isabella | Isabella II of Spain | Castile (historical region) | Tony Isabella | Philip I of Castile | Alfonso VIII of Castile | Joanna of Castile | Isabella Stewart Gardner | Eleanor of Castile | Castile-La Mancha | Isabella Rossellini | Alfonso XI of Castile | Henry II of Castile | Ferdinand III of Castile | Peter of Castile | John I of Castile | John II of Castile | Isabella Boschetti | Order of Isabella the Catholic | Isabella of Portugal | Henry III of Castile | Guadalajara, Castile-La Mancha | Blanche of Castile | Sancho IV of Castile | Sancho III of Castile |
# Infanta Isabella of Castile (1372–1392) – The wife of Edmund of Langley, Isabella predeceased her husband and died at Kings Langley Manor House in Hertfordshire, England.
The Spanish monarchs Ferdinand and Isabella were known to be fearful of a new rapprochement between Louis XII and the Italian powers.
Ferdinand II of Aragon, who married Isabella of Castile to become king of Spain, (1452–1516)