His district was renumbered as the 1st District as a result of the 2000s (decade) round of redistricting, and became even more Democratic with the addition of much of Iowa's share of the Quad Cities.
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His position brought national and international interest to his district, including the ONE Campaign, the lobbying group formed by Bono of the rock band U2.
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On March 23, 2006 they placed a statement in Nussle's article on Wikipedia, regarding poverty in Africa and Nussle's budget influence, hoping to influence Nussle.
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