He was second son of John Grobham Howe of Langar, Nottinghamshire, who was member of parliament for Gloucestershire.
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He took an active part against Gilbert Burnet for his 'Pastoral Letter,' and spoke vehemently against the prosecution of the war and on behalf of Sir John Fenwick.
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In 1679 he brought an accusation against Frances Stewart, Duchess of Richmond, which on investigation proved to be false, and he was forbidden to attend the court.
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He was the fourth son of John Grubham Howe of Langar in Nottinghamshire; his older brother, Scrope Howe, was a prominent Whig politician and was raised to the peerage as Viscount Howe in 1701.