He is mainly known for his Horae Ebraicae et Talmudicae in universum Novum Testamentum (1733) which follows on the model of John Lightfoot's use of Talmudic insights for commentary on the New Testament.
From Stone he removed to Hornsey, near London, for the sake of reading in the library of Sion College.
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In the course of 1686 James II discovered that John Lightfoot had not taken the oaths when he was admitted to his master's degree at Cambridge, and he furnished with royal letters patent a Roman Catholic candidate for the degree, the Benedictine monk Alban Francis .
In the Westminster Assembly a party holding this view included John Selden, John Lightfoot, Thomas Coleman and Bulstrode Whitelocke, whose speech (1645) is appended to Lee's version of the Theses; but the opposite view, after much controversy, was carried, Lightfoot alone dissenting.