Several portions of SR 50 east of SR 436 follow the original Cheney Highway, which was named for John Moses Cheney and was the first road to the coast from Orlando.
He unsuccessfully ran as the Republican candidate in the 1920 Senate election.
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The road in east-central Florida that became State Road 50 was named after him in 1924; portions of the road remain and are called the Old Cheney Highway.
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