Having earned the nickname 'The Wall' for his consistent defensive displays, Santamaría retired at the end of the 1965–66 campaign at the age of nearly 39, featuring twice in that year's European Cup en route to another triumph (against Feyenoord and at Kilmarnock).
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Born in Montevideo to Spanish parents, Santamaría played for local Club Nacional de Football in his country, winning five national championships during his spell.
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Played against the greatest players in the world such as: Pele, Di Stéfano, Zagallo, Puskás, Didi, Garrincha, Santos, Santa Maria, Bobby Moore, Geoff Hurst, also played with the greatest stars the Arabs : Ammo Baba, from Iraq, Sidiik Mnzul, Borai Abdalkhar, from Sudan, Chicha of Morocco, Hassan Al-Amir, from Algeria .