It and the parallel effort by Walter Goad which led to the GenBank database of nucleic acid sequences are the twin origins of the modern databases of molecular sequences.
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The one-letter code used for amino acids was developed by her, reflecting an attempt to reduce the size of the data files used to describe amino acid sequences in an era of punch-card computing.
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Frederick Sanger's determination of the first complete amino acid sequence of a protein (insulin) in 1955, led a number of researchers to sequence various proteins from different species.
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She taught physiology and biophysics for 13 years, while becoming affiliated with the National Biomedical Research Foundation, a Fellow of the American Association for the Advancement of Science, a councillor of the International Society for the Study of the Origins of Life (1980) and acting on the editorial boards of DNA, Journal of Molecular Evolution and Computers in Biology and Medicine.
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