Except for Nama, they are under pressure from national or regional languages such as Tswana.
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Tom Güldemann believes agro-pastoralist people speaking the Khoe–Kwadi proto-language entered modern-day Botswana about 2000 years ago from the northeast (that is, in the direction of the modern Sandawe), where they had likely acquired agriculture from the expanding Bantu, at a time when the Kalahari was more amenable to agriculture.
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They were once considered to be a branch of a Khoisan language family, and were known as Central Khoisan in that scenario.
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The second point of transfer was near the Caprivi Strip and the Okavango River where, apparently, the Yeyi language borrowed the clicks from a West Kalihari Khoe language; a separate development lead to a smaller click inventory in the neighboring Mbukushu, Kwangali, Gciriku, Kuhane, and Fwe languages in Angola, Namibia, Botswana, and Zambia.