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The 1981 All-Ireland Senior Club Camogie Championship for the leading clubs in the women's team field sport of camogie was won by Buffers Alley from Wexford, who defeated Killeagh from Cork in the final, played at Gaultier .
The championship was organised on the traditional provincial system used in Gaelic Games since the 1880s, with Killeagh and Portglenone winning the championships of the other two provinces.