In 1838 the hospital cared for its first patients, twenty wounded Americans taken prisoner in the Battle of the Windmill during the Rebellion of 1837.
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Three years later, renovations made way for new facilities including laboratories, ophthalmology, prosthetics, endoscopy, renal unit and a pulmonary function lab; space for the KGH Auxiliary was also added.
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Since the completion of the last RSL, the Kingston General Hospital has been demolished and the organisation has relocated to new studio at the Hull Royal Infirmary on Anlaby Road, which has been equipped with a computerised play out system called "Myriad", re-writeable CD recorders, MiniDisc and, since 2011, Flash Drive players.