When Louis Pasteur created a vaccine against rabies in 1886, Kristaps Helmanis devoted himself to research of rabies in St Petersburg and reported his results to the Duke Alexander Petrovich of Oldenburg, who supported his studies.
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Helmanis was born on 3 June 1848 in Tērvete (then Hofzumberge, Courland Governorate), received education at the parish school and Jelgava Real School (Jelgavas reālskola).