90-100% of patients with a clinical diagnosis of PJS have a mutation in the STK11/LKB1 gene.
STRAD and MO25 together cooperate to promote LKB1 active conformation.
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The LKB1 activation loop, a critical element in the process of kinase activation, is held in place by MO25, thus explaining the huge increase in LKB1 activity in the presence of STRAD and MO25 .