Orgel died of cancer on 27 October 2007 at the San Diego Hospice & Palliative Care in San Diego, California.
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He was also an adjunct professor in the Department of Chemistry and Biochemistry at the University of California, San Diego, and he was one of five principal investigators in the NASA-sponsored NSCORT program in exobiology.
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Born in London, England, Orgel received his Bachelor of Arts degree in chemistry with first class honours from the University of Oxford in 1949.
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