The allegiance of Felix to Canterbury determined the Roman basis of the East Anglian Church, though his training in Burgundy may have been coloured by the teaching of the Irish missionary Columbanus in Luxeuil.
In 731 a raiding party of Moors under the skilful general, Abdul Rahman Al Ghafiqi, governor of Al-Andalus, penetrating from Arles deep into Burgundy, briefly took possession of Luxeuil and massacred most of the community.
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Luxeuil sent out monks to found houses at Bobbio, between Milan and Genoa, where Columbanus himself became abbot, and monasteries at Saint-Valéry and Remiremont.
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To Luxeuil came such monks as Conon, abbot of Lérins Abbey to prepare for the reform of his monastery, and Saints Wandregisel and Philibert, founders respectively of the abbeys of Fontenelle and Jumièges in Normandy, who spent years in studying the rule observed in monasteries which derived their origin from Luxeuil.
The abbot of Luxeuil, Saint Waldebert, sent Saint Germanus of Granfelden, who served 35 years as the first abbot, with Saint Randoald of Grandval as his prior.
Among its celebrated abbeys the diocese counted those of St. Memmius, founded in the fifth century by Alpinus; Toussaints, founded in the eleventh century; Montier-en-Der, founded in the seventh century by St. Bereharius, a monk from Luxeuil; Saint-Pierre au Mont, founded during the same period.
:Another St. Theofrid (or Théofroy) was a 7th-century monk at Luxeuil who became abbot of Corbie and a bishop.