The expression profile in mouse of the co-regulated Meg3 and Dlk1 genes suggests a causative role in the pathologies found in uniparental disomy animals, characterized by defects in skeletal muscle maturation, bone formation, placenta size and organization and prenatal lethality.
He has applied his methods to the identification and mapping of genes affecting economically important single-gene (e.g. polled, double-muscling, callipyge, weaver, congenital muscular distonia), as well as complex multi-gene traits (e.g. milk and fattening yield and quality, fertility, disease resistance).
MEG3 |