Interestingly, MEN1 gene (11q13.1) is most frequently deleted, while GARP gene (11q13.5) may also be involved.
HOXA9 expression is regulated by several genes, including UTX, WHSC1, MLL and MEN1.
The MEN1 gene consists of ten exons, spanning about 10 kb, and encodes a 610 amino acid protein named menin.
# DNA repair proteins are usually classified as tumor suppressors as well, as mutations in their genes increase the risk of cancer, for example mutations in HNPCC, MEN1 and BRCA.
MEN1 |
In all cases, the disease is idiopathic, but is thought to involve inactivation of tumor suppressor genes (Menin gene in MEN1), or involve gain of function mutations (RET proto-oncogene MEN 2a).