The film's success was followed by another episode, Mano Po 2: My Home and a spin off, Bahay Kubo: A Pinoy Mano Po! that has released in 2007.
Mano Po III: My Love is the third installment of the Mano Po Anthology, following the success of Mano Po and Mano Po 2: My Home.
Mano Negra | Mano River Union | Segunda Mano | Mano Solo | Mano Po 6: A Mother's Love | Mano Po 5: Gua Ai Di | Mano Po | Mano Ganesan | Mano Dayak | Mano a Mano | La Mano Ajena | Erina Mano | Bahay Kubo: A Pinoy Mano Po! |
Regal Films' Mano Po 6: A Mother's Love won six awards--- Best Actress (Sharon Cuneta); Best Supporting Actress (Heart Evangelista); Best Director (Joel Lamangan); Best Screenplay (Roy Iglesias); Best Musical Score (Von de Guzman) and Gatpuno Antonio J. Villegas Cultural Awards.
Aside from her Mano Po appearance, Regal Films also made Bianca to be part of I Will Always Love You starred by Richard Gutierrez and Angel Locsin.
Unlike its earlier predecessors and the following installment Mano Po 6: A Mother's Love, Mano Po 5 is rather more of a romantic comedy-drama than the purely drama genre.
Mano Po 6: A Mother's Love is the sixth installment in the Mano Po film franchise, following Mano Po 5: Gua Ai Di in 2006.