She notably created roles in the world premieres of operas by Vincenzo Bellini, Gaetano Donizetti, Simon Mayr, Giovanni Pacini, Luigi Ricci, and Giuseppe Verdi.
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In 1826 she sang in the premiere of Giovanni Pacini's La gelosia corretta at La Scala and returned to that house the following year to perform the role of Adele in the world premiere of Vincenzo Bellini's Il pirata.
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In 1823 Sacchi portrayed the role of Barsene in the world premiere of Simon Mayr's Demetrio at the Teatro Regio di Torino.
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In 1836 Sacchi was committed to the Teatro Comunale di Bologna where she portrayed Eudora in Donizetti's Belisario and Imelda in Donizetti's Parisina among other roles.
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