The main piece of art is a polyptych of St. Syrus (1516), once attributed to Teramo Piaggio, now assigned to Pier Francesco Sacchi.
It houses numerous artworks commissioned by the main noble families of Genoa, by artists such as Francesco Maria Schiaffino, Lorenzo Fasolo, Alessandro Gherardini, Giuseppe Palmieri, Francesco Boccaccino, Pier Francesco Sacchi, Bernardo Castello, Aurelio Lomi and Tommaso Orsolino.
Pier Paolo Pasolini | Francesco Rosi | Francesco Clemente | Francesco Bartolozzi | Francesco Guardi | Navy Pier | Francesco Guccini | Francesco Marino Mannoia | Francesco Severi | Francesco Cossiga | Pier 39 | Francesco Moser | Francesco Mondada | Gian Francesco Malipiero | West Pier | Steel Pier | Santa Monica Pier | Pier Luigi Nervi | pier | Giovanni Francesco Fara | Francesco Redi | Francesco Quinn | Francesco Graziani | Francesco De Gregori | Francesco Crispi | Francesco Conconi | Francesco Barberini | Ryde Pier | Pier Michele Giagaraccio | Pier Ferdinando Casini |