The major buildings were designed by Chicago architect Edo Belli, whose firm conducted a longstanding collaboration with the Daughters of Charity in several states.
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Many hospitals, orphanages, and educational institutions were established and operated by the Daughters of Charity over the years, including Saint Joseph College, Emmitsburg, Maryland, Marillac College in Missouri, Santa Isabel College Manila, Saint Louise's Comprehensive College in Belfast, Northern Ireland, and Saint Louise de Marillac High School in Illinois.