In 1955, he opened The Isaacs Gallery where he represented numerous Canadian artists, including Michael Snow, Graham Goughtry, Gordon Rayner, Jack Chambers, Joyce Wieland, Mark Prent, John Meredith, Robert Markle and Gathie Falk.
In 1974, Mark Prent's friend, installation artist Edward Kienholz, secured Prent an invitation to live and work in Berlin, Germany via the German Academic Exchange Service.
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In that same year he graduated, Prent exhibited two uniquely disturbing entries in "Survey '70", an exhibit of Canadian avant garde artists organized by the Montreal Museum of Fine Arts.
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