The HKA Test, named after Richard R. Hudson, Martin Kreitman, and Montserrat Aguadé, is a statistical test used in genetics to evaluate the predictions of the Neutral Theory of molecular evolution.
In 1999, under the new joint editorship of Martin Kreitman (the current editor-in-chief), Takashi Gojobori, and Giorgio Bernardi, the journal made explicit its focus on "the fundamental issues in molecular evolution", to the exclusion of molecular phylogenetics (the purview of several other molecular evolution journals, most significantly Molecular Phylogenetics and Evolution) and origin of life research, except in cases that have "a special significance and impact".
In 1991, John H. McDonald and Martin Kreitman derived the McDonald–Kreitman test while performing an experiment with Drosophila (fruit flies) and their differences in amino acid sequence of the alcohol dehydrogenase gene.
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