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These now focused on a single institution, the original and by this time extremely large Arcispedale di Santo Spirito in Sassia, the buildings of which dated from the time of Pope Sixtus IV (1471–84), which at its height was capable of accommodating over 1,000 patients, with additional spaces for contagious and for dangerously insane cases, and more than 100 medical staff, and an international remit.