The named trains Great Northern Empire Builder, Chicago, Burlington and Quincy Twin Cities Zephyr, Chicago and North Western Twin Cities 400, and Northern Pacific North Coast Limited either passed through or terminated at the Depot.
At Target Field station, the parallel rail lines of the old Great Northern Railway (north side track now BNSF) and the Minneapolis and St. Louis Railway (south side track now Union Pacific) travel eastbound past the Federal Reserve Bank, the site of the old Minneapolis Great Northern Depot, across the Mississippi River on the Minneapolis BNSF Rail Bridge, and then across Nicollet Island.
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