NMYC interactor (NMI) interacts with NMYC and CMYC (two members of the oncogene Myc family), and other transcription factors containing a Zip, HLH, or HLH-Zip motif.
Notably, MYC was found to directly control BYSL, a highly conserved, but poorly characterized gene, and is the largest hub in the whole B cell network.
Nuclear LIM interactor (NLI) / LIM domain-binding protein 1 (LDB1) is located in the nuclei of neuronal cells during development, it is co-expressed with ISL1 in early motor neuron differentiation and has a suggested role in the ISL1 dependent development of motor neurons.
Knoepfler did his postdoctoral studies at the Fred Hutchinson Cancer Research Center in the laboratory of Bob Eisenman, studying Myc regulation of chromatin in stem cells and cancers of the nervous system.
Stauprimide interacts with NME2 (PUF) transcription factor to down-regulate c-Myc expression, leading to differentiation of stem cells.