It was developed as a potential analgesic after the discovery that the selective ziconotide is an active analgesic with similar efficacy to strong opioid drugs but comparatively milder side effects.
Channel 4 | Discovery Channel | Disney Channel | type species | National Geographic Channel | English Channel | Nickelodeon (TV channel) | Fox News Channel | Channel Islands | History (U.S. TV channel) | Travel Channel | Clear Channel Communications | TLC (TV channel) | type | Channel Tunnel | virtual channel | Channel Islands of California | The Weather Channel | The Filipino Channel | The History Channel | Type (biology) | Mega Channel | Hallmark Channel | Diabetes mellitus type 1 | YTV (TV channel) | TNT (TV channel) | List of Disney Channel Original Movies | Bristol Channel | Type O Negative | AMC (TV channel) |
The dual effect of seletracetam is an overall decrease in the amount of action potential due to binding at N-type channels, which prevents over-excitation of the neuron, as well as a decrease in neurotransmitter release as a product of cellular excitation due to the interaction of the drug with SV2A, which reduces the spread of excitation to nearby cells.
Unlike ziconotide, TROX-1 is not so selective, and also blocks the intrathecally, by injection into the spinal fluid.