X-Nico

2 unusual facts about Nazarov cyclization reaction


Nazarov cyclization reaction

Along this same vein, allenyl vinyl ketones of the type studied extensively by Marcus Tius of the University of Hawaii show dramatic rate acceleration due to the removal of β-hydrogens, obviating a large amount of steric strain in the s-cis conformer.

Torquoselectivity

An example of the latter case is shown below for the torquoselective Nazarov cyclization reaction of a chiral allenyl vinyl ketone.



see also