Chromatic aberration, spherical aberration and the dependence on natural light all played a role in limiting microscope performance in the early 19th century.
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Heinrich Wilhelm Gottfried von Waldeyer-Hartz (6 October 1836, Hehlen an der Weser, Braunschweig, Germany – 23 January 1921, Berlin) was a German anatomist, famous for consolidating the neuron theory of organization of the nervous system and for naming the chromosome.