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The dissensions between Cardinal Nicholas of Cusa (1450-1464), appointed by Pope Nicholas V as Bishop of Brixen, and the Austrian Archduke Sigismund of Habsburg were also unfortunate; the cardinal was made a prisoner, and although the pope placed the diocese under an interdict, Sigismund came out victor in the struggle.
This approval of slavery was reaffirmed and extended in the Romanus Pontifex bull of 1455 (also by Nicholas V).
Pope Pius V ordered the construction of a chapel strictly reserved for the Guards behind the bastion of Nicholas V. The construction of the building dates back to 1568 under the direction of architect Nanni di Baccio Bigio.