He is a caporegime in the Corleone crime family, but later betrays the family, and becomes a sworn enemy to Don Michael Corleone.
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His injuries in the ring eventually lead to him developing Parkinson's disease.
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The original novel implies Tessio's death, but Mark Winegardner's sequel novel The Godfather Returns explains that he is executed with a gunshot at point blank range by his enforcer Nick Geraci.