This bifunctional enzyme is named UMP synthase and it also catalyzes the preceding reaction in pyrimidine nucleotide biosynthesis, the transfer of ribose 5-phosphate from 5-phosphoribosyl-1-pyrophosphate to orotate to form OMP.
phosphate | Nicotinamide adenine dinucleotide phosphate | Phosphate | British Phosphate Commission | Imidazoleglycerol-phosphate dehydratase | Glucose-6-phosphate dehydrogenase deficiency | Uroporphyrinogen III decarboxylase | Ribose-5-phosphate isomerase deficiency | Phosphate minerals | Phosphate conversion coating | Pentose phosphate pathway | Orotidine 5'-monophosphate | orotidine-5'-monophosphate | Ornithine decarboxylase antizyme | Nauru Phosphate Corporation | N-acetylglucosamine-1-phosphate transferase | lithium iron phosphate | Histidine decarboxylase | Glutamate decarboxylase | Glucose-6-phosphate dehydrogenase | Dihydroxyacetone phosphate | Dicalcium phosphate |
Dihydroorotate is synthesized to orotic acid by the enzyme dihydroorate dehydrogenase, where it later combines with phosphoribosyl pyrophosphate (PRPP) to form orotidine-5'-monophosphate (OMP).