In 1894 with pathologist Otto Busse (1867–1922), Buschke described an infectious disease caused by the fungus Cryptococcus neoformans.
In 1894 Busse was the first to provide a written account of cryptococcosis, caused by a yeast-like fungus now known as Cryptococcus neoformans.
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In 1901 he transferred the yeast-like fungus that was named Saccharomyces hominis by Otto Busse and Saccharomyces neoformans by Francesco Sanfelice to the genus Cryptococcus due to its absence of ascospores.