Alpers' disease is caused by an underlying mitochondrial metabolic defect of POLG,.
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Alpers' disease is caused by certain genetic mutations in the POLG gene.
Dominant and recessive forms of PEO can be caused by genetic mutations in the ANT1, POLG, POLG2 and PEO1 genes.
The POLG2 gene encodes a 55 kDa accessory subunit protein that imparts high processivity and salt tolerance to the catalytic subunit of DNA polymerase gamma, encoded by the POLG gene.
POLG |