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He was born in Mula, region of Murcia, a great-grandson of Luis de Zúñiga y Requesens and the son of Luis Fajardo Requesens y Zúñiga, Marqués de los Vélez, (1576–1631), the preceding Viceroy of Valencia, 1628–1631, deceased 1631, 4th Marqués de los Vélez.