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In 1863/4 he studied physics, mathematics, and physiology in the University of Paris, and on his return he filled successively chairs in Pennsylvania College, Gettysburg, and Lehigh University, Bethlehem, from 1865 to 1870.
Sadtler was born at Pine Grove, Pa., the son of a Lutheran minister, and educated at Pennsylvania College (class of 1867), at Lehigh University (one year), at Lawrence Scientific School (BSc 1870), and in Europe at the University of Göttingen (PhD 1871).