It follows the routing of Old York Road, a historic road that connected Philadelphia to New York City, and carries the name York Road from the southern terminus to Lahaska and Upper York Road north of there.
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What is now PA 263 was originally built as part of the Old York Road, a road established in the 18th century to connect Philadelphia to New York City.
In 2006, Pennsylvania Route 263 through Hatboro was named the Roy W. Cornell Memorial Highway in his honor.
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Old York Road deviates from PA 611, at the intersection with Easton Road in Willow Grove where it runs concurrently with PA 263.
PA 332 begins at an intersection with PA 263 (York Road) in Hatboro, Montgomery County, heading east on Montgomery Avenue, a two-lane undivided roadway.