The route runs from Pennsylvania Route 82 in West Nantmeal Township, Chester County north to U.S. Route 422 near Birdsboro, Berks County.
Pennsylvania | University of Pennsylvania | Pennsylvania State University | Pennsylvania Railroad | Harrisburg, Pennsylvania | Pennsylvania House of Representatives | Erie, Pennsylvania | Carlisle, Pennsylvania | Williamsport, Pennsylvania | Scranton, Pennsylvania | West Chester, Pennsylvania | Montgomery County, Pennsylvania | Lancaster, Pennsylvania | Bethlehem, Pennsylvania | U.S. Route 66 | Hershey, Pennsylvania | York, Pennsylvania | U.S. Route 1 | Pennsylvania Turnpike | Pennsylvania Academy of the Fine Arts | Wharton School of the University of Pennsylvania | University Park, Pennsylvania | Wilkes-Barre, Pennsylvania | Johnstown, Pennsylvania | Gettysburg, Pennsylvania | Reading, Pennsylvania | Luzerne County, Pennsylvania | Allentown, Pennsylvania | Abington Township, Montgomery County, Pennsylvania | U.S. Route 6 |