In the village of North Springfield, PA 5 intersects the northern terminus of Pennsylvania Route 215.
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The route begins in suburban Millcreek Township where its parent route passes near Erie International Airport.
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At the north end of the bridge, the PA 299 designation ends and Powell Avenue continues north as a local road past Erie International Airport, intersecting PA 5 (West 12th Street) and PA 5 Alternate (West Lake Road) before continuing several more blocks to the Lake Erie shoreline.